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Environ Res. 2015 Feb;137:419-23. doi: 10.1016/j.envres.2015.01.010. Epub 2015 Jan 23.

Urinary phthalate metabolites are associated with insulin resistance in obese subjects.

Author information

1
Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Edegem, Belgium, University of Antwerp, Antwerp, Belgium. Electronic address: eveline.dirinck@uza.be.
2
Toxicology Centre, University of Antwerp, Antwerp, Belgium.
3
Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Edegem, Belgium, University of Antwerp, Antwerp, Belgium.
4
Department of Clinical Pharmacology, Antwerp University Hospital, Edegem, Belgium, University of Antwerp, Antwerp, Belgium.

Abstract

Phthalates are potentially involved in the development of type 2 diabetes mellitus. In a cohort of 123 obese subjects, 10 phthalate metabolites were analyzed. An oral glucose tolerance test was performed and various estimates of insulin resistance and beta-cell function were calculated. After adjustment for age, physical activity level, smoking behavior, medication use and body mass index, several phthalate metabolites were linked to markers of glucose tolerance and insulin resistance.

KEYWORDS:

Beta-cell function; Diabetes; Insulin resistance; Obesity; Oral glucose tolerance test; Phthalates

PMID:
25622280
DOI:
10.1016/j.envres.2015.01.010
[Indexed for MEDLINE]

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