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Clin Breast Cancer. 2015 Jun;15(3):181-90.e1-4. doi: 10.1016/j.clbc.2014.12.006. Epub 2014 Dec 24.

Three-Arm Randomized Phase III Trial: Quality Aloe and Placebo Cream Versus Powder as Skin Treatment During Breast Cancer Radiation Therapy.

Author information

1
KADA Consulting, Edmonton, AB, Canada.
2
BC Cancer Agency Vancouver Island Centre, Victoria, BC, Canada.
3
Department of Radiation Oncology, Cross Cancer Institute, Edmonton, AB, Canada.
4
University of Texas MD Anderson Cancer Center, Houston, TX, and Henry Ford Health Science Center, Henry Ford Hospital, Detroit, MI.
5
Division of Population Health and Information, Cross Cancer Institute, Edmonton, AB, Canada.
6
Department of Medical Oncology, Cross Cancer Institute, Edmonton, AB, Canada.
7
Department of Radiation Oncology, Cross Cancer Institute, Edmonton, AB, Canada. Electronic address: diane.severin@albertahealthservices.ca.

Abstract

BACKGROUND:

The efficacy of aloe extract in reducing radiation-induced skin injury is controversial. The purpose of the present 3-arm randomized trial was to test the efficacy of quality-tested aloe extract in reducing the severity of radiation-induced skin injury and, secondarily, to examine the effect of a moist cream versus a dry powder skin care regimen.

MATERIALS AND METHODS:

A total of 248 patients with breast cancer were randomized to powder, aloe cream, or placebo cream. Acute skin toxicity was scored weekly and after treatment at weeks 1, 2, and 4 using a modified 10-point Catterall scale. The patients scored their symptom severity using a 6-point Likert scale and kept an acute phase diary.

RESULTS:

The aloe formulation did not reduce acute skin toxicity or symptom severity. Patients with a greater body mass index were more likely to develop acute skin toxicity. A similar pattern of increased skin reaction toxicity occurred with both study creams compared with the dry powder regimen.

CONCLUSION:

No evidence was found to support prophylactic application of quality aloe extract or cream to improve the symptoms or reduce the skin reaction severity. Our results support a dry skin care regimen of powder during radiation therapy.

KEYWORDS:

Aloe vera; Catterall skin scoring profile; Prevention; Radiotherapy; Skin reactions

PMID:
25619686
DOI:
10.1016/j.clbc.2014.12.006
[Indexed for MEDLINE]

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