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Wiley Interdiscip Rev Dev Biol. 2015 May-Jun;4(3):299-309. doi: 10.1002/wdev.175. Epub 2015 Jan 23.

Asymmetric cell division in the Drosophila bristle lineage: from the polarization of sensory organ precursor cells to Notch-mediated binary fate decision.

Author information

1
Institut Pasteur, Paris, France; CNRS URA2578, Paris, France.

Abstract

Asymmetric cell division (ACD) is a simple and evolutionary conserved process whereby a mother divides to generate two daughter cells with distinct developmental potentials. This process can generate cell fate diversity during development. Fate asymmetry may result from the unequal segregation of molecules and/or organelles between the two daughter cells. Here, I will review how fate asymmetry is regulated in the sensory bristle lineage in Drosophila and focus on the molecular mechanisms underlying ACD of the sensory organ precursor cells (SOPs). For further resources related to this article, please visit the WIREs website.

PMID:
25619594
PMCID:
PMC4671255
DOI:
10.1002/wdev.175
[Indexed for MEDLINE]
Free PMC Article

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