Activatable photodynamic destruction of cancer cells by NIR dye/photosensitizer loaded liposomes

Chem Commun (Camb). 2015 Feb 25;51(16):3340-2. doi: 10.1039/c4cc09689d.

Abstract

The phototoxicity of Chlorin e6 (Ce6) for photodynamic therapy (PDT) was found to be effectively suppressed by indocyanine green (ICG), a near infrared (NIR) dye. Upon NIR laser irradiation at 808 nm, ICG in the liposomes containing ICG and Ce6 could be degraded, while the phototoxicity of Ce6 could be recovered. In addition, we demonstrate that this newly developed liposomal component can be successfully used for activatable PDT to destroy cancer cells in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • Chlorophyllides
  • Coloring Agents / administration & dosage*
  • Coloring Agents / pharmacology*
  • Indocyanine Green / administration & dosage
  • Indocyanine Green / pharmacology
  • Infrared Rays*
  • Liposomes
  • Neoplasms / pathology*
  • Photochemotherapy / methods*
  • Photosensitizing Agents / administration & dosage*
  • Photosensitizing Agents / pharmacology*
  • Porphyrins / administration & dosage
  • Porphyrins / pharmacology

Substances

  • Chlorophyllides
  • Coloring Agents
  • Liposomes
  • Photosensitizing Agents
  • Porphyrins
  • phytochlorin
  • Indocyanine Green