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Am J Hypertens. 2015 Aug;28(8):1031-7. doi: 10.1093/ajh/hpu263. Epub 2015 Jan 23.

Variant Near FGF5 Has Stronger Effects on Blood Pressure in Chinese With a Higher Body Mass Index.

Author information

1
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA; Curriculum in Bioinformatics & Computational Biology, University of North Carolina, Chapel Hill, North Carolina, USA;
2
Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China;
3
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA;
4
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA;
5
Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA;
6
Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, USA; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA;
7
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA; Present address: Program for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA (J.X., S.L.Z.); Center for Genomic Translational Medicine and Prevention, Fudan School of Public Health, Fudan University, Shanghai, P.R. China (J.X.); Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, P.R. China (S.L.Z.).
8
Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China;
9
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA; Curriculum in Bioinformatics & Computational Biology, University of North Carolina, Chapel Hill, North Carolina, USA; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA; elange@med.unc.edu.

Abstract

BACKGROUND:

The objective of this study was to investigate the genetic association of 4 candidate variants with blood pressure and test the modifying effects of environmental factors including age, sex, and body mass index (BMI).

METHODS:

We used a linear mixed-effects model to test for variant main effects and variant interactions with age, sex, and BMI on systolic (SBP) and diastolic (DBP) blood pressure in 7,319 Chinese adults from the China Health and Nutrition Survey (CHNS). We attempted to replicate our significant interaction findings in 1,996 Chinese men from the Fangchenggang Area Male Health and Examination Survey (FAMHES).

RESULTS:

Two variants (rs11105378 near ATP2B1 and rs1458038 near FGF5) were significantly associated (P < 0.00625 = 0.05/8) with both SBP and DBP in CHNS. Variant rs1378942 near CSK was nominally associated with SBP (P = 0.01). The signal at rs1458038 exhibited a genotype-by-BMI interaction affecting blood pressure (P interaction = 0.0018 for SBP; P interaction = 0.049 for DBP), with the strongest variant effects in those with the highest BMI. In FAMHES, rs1458038 also showed stronger effects on SBP and DBP among men with the highest BMI.

CONCLUSIONS:

Our findings suggest high BMI increases the effect of the blood pressure-increasing allele at rs1458038 near FGF5, further highlighting the importance of obesity prevention in reducing hypertension risk.

KEYWORDS:

BMI; FGF5; blood pressure; hypertension; interaction.

PMID:
25618516
PMCID:
PMC4542636
DOI:
10.1093/ajh/hpu263
[Indexed for MEDLINE]
Free PMC Article

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