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Gait Posture. 2015 Feb;41(2):592-6. doi: 10.1016/j.gaitpost.2015.01.004. Epub 2015 Jan 10.

Toward new sensitive measures to evaluate gait stability in focal cerebellar lesion patients.

Author information

1
Movement Control and Neuroplasticity Research Group, Department of Kinesiology, KU Leuven, Belgium. Electronic address: wouter.hoogkamer@faber.kuleuven.be.
2
Movement Control and Neuroplasticity Research Group, Department of Kinesiology, KU Leuven, Belgium; Department of Orthopedics, First Affiliated Hospital of Fujian Medical University, PR China; MOVE Research Institute, VU University Amsterdam, The Netherlands.
3
Department of Radiology, University Hospitals Leuven, Belgium; Department of Imaging & Pathology, KU Leuven, Belgium.
4
Movement Control and Neuroplasticity Research Group, Department of Kinesiology, KU Leuven, Belgium.
5
Department of Neurosurgery, University Hospitals Leuven, Belgium.
6
Movement Control and Neuroplasticity Research Group, Department of Kinesiology, KU Leuven, Belgium; Department of Research, Development & Education, St. Maartenskliniek Nijmegen, The Netherlands.

Abstract

The evident ataxic characteristics of gait in patients with cerebellar damage suggest that the cerebellum plays an important role in the neural control of gait. Ataxic features, such as increased gait variability and increased step width, are often related to gait stability. However, the link between these measures and gait stability is not straightforward. Therefore, to gain more insights into relations between gait stability, gait variability and gait ataxia, we quantified gait stability using the short-term maximum Lyapunov exponent. This is a more valid measure of gait stability, derived from dynamical systems theory. Eighteen patients with focal cerebellar lesions after tumor resection walked on an instrumented treadmill at 1.0m/s for 3min. The patients displayed relatively mild functional deficits (ICARS=6.9±6.4, range 0-20) and had a lower overground walking speed as compared to healthy controls (1.12m/s versus 1.31m/s). During treadmill walking, the short-term maximum Lyapunov exponent was higher in cerebellar patients, indicating reduced gait stability. Furthermore, step width was increased in the patient group while other spatio-temporal gait parameters were similar. Patients with the largest lesions in the vermis displayed the least stable gait pattern. These observations imply that the short-term maximum Lyapunov exponent is a sensitive measure of gait deficits in mildly ataxic cerebellar patients.

KEYWORDS:

Ataxia; Cerebellum; Locomotion; Short-term maximum Lyapunov exponent; Vermis

PMID:
25618477
DOI:
10.1016/j.gaitpost.2015.01.004
[Indexed for MEDLINE]

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