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Blood. 2015 Mar 5;125(10):1521-5. doi: 10.1182/blood-2014-11-567925. Epub 2015 Jan 23.

Long-range gene regulation and novel therapeutic applications.

Author information

1
Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands;
2
INSERM UMRS 1138, Team 17, Paris, France; and.
3
INSERM UMR967, CEA/DSV/iRCM, Laboratory of Molecular Hematopoiesis, Fontenay-aux-Roses, France.

Abstract

An intimate relationship exists between nuclear architecture and gene activity. Unraveling the fine-scale three-dimensional structure of the genome and its impact on gene regulation is a major goal of current epigenetic research, one with direct implications for understanding the molecular mechanisms underlying human phenotypic variation and disease susceptibility. In this context, the novel revolutionary genome editing technologies and emerging new ways to manipulate genome folding offer new promises for the treatment of human disorders.

PMID:
25617428
DOI:
10.1182/blood-2014-11-567925
[Indexed for MEDLINE]

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