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Int J Epidemiol. 2015 Aug;44(4):1388-96. doi: 10.1093/ije/dyu277. Epub 2015 Jan 22.

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936.

Author information

1
Centre for Cognitive Ageing and Cognitive Epidemiology, and Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK, Queensland Brain Institute, and.
2
Queensland Brain Institute, and Translational Research Institute, University of Queensland, Brisbane, QLD, Australia.
3
Centre for Cognitive Ageing and Cognitive Epidemiology, and Department of Psychology, University of Edinburgh, Edinburgh, UK.
4
MRC Unit for Lifelong Health and Ageing, London, UK.
5
Centre for Cognitive Ageing and Cognitive Epidemiology, and Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.
6
Wellcome Trust Clinical Research Facility, and.
7
Department of Psychology, University of Edinburgh, Edinburgh, UK.
8
Centre for Cognitive Ageing and Cognitive Epidemiology, and Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK and.
9
Gonda Research Center, David Geffen School of Medicine, Los Angeles, CA, USA.
10
Centre for Cognitive Ageing and Cognitive Epidemiology, and Queensland Brain Institute, and Translational Research Institute, University of Queensland, Brisbane, QLD, Australia.
11
Translational Research Institute, University of Queensland, Brisbane, QLD, Australia.
12
Centre for Cognitive Ageing and Cognitive Epidemiology, and Department of Psychology, University of Edinburgh, Edinburgh, UK, i.deary@ed.ac.uk.

Abstract

BACKGROUND:

The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength and cognitive ability.

METHODS:

DNA methylation-based age acceleration (residuals of the epigenetic clock estimate regressed on chronological age) were estimated in the Lothian Birth Cohort 1936 at ages 70 (n = 920), 73 (n = 299) and 76 (n = 273) years. General cognitive ability, walking speed, lung function and grip strength were measured concurrently. Cross-sectional correlations between age acceleration and the fitness variables were calculated. Longitudinal change in the epigenetic clock estimates and the fitness variables were assessed via linear mixed models and latent growth curves. Epigenetic age acceleration at age 70 was used as a predictor of longitudinal change in fitness. Epigenome-wide association studies (EWASs) were conducted on the four fitness measures.

RESULTS:

Cross-sectional correlations were significant between greater age acceleration and poorer performance on the lung function, cognition and grip strength measures (r range: -0.07 to -0.05, P range: 9.7 x 10(-3) to 0.024). All of the fitness variables declined over time but age acceleration did not correlate with subsequent change over 6 years. There were no EWAS hits for the fitness traits.

CONCLUSIONS:

Markers of physical and mental fitness are associated with the epigenetic clock (lower abilities associated with age acceleration). However, age acceleration does not associate with decline in these measures, at least over a relatively short follow-up.

KEYWORDS:

DNA methylation; cognitive function; epigenetic clock; fitness; longitudinal

PMID:
25617346
PMCID:
PMC4588858
DOI:
10.1093/ije/dyu277
[Indexed for MEDLINE]
Free PMC Article

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