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Expert Rev Gastroenterol Hepatol. 2015 Apr;9(4):519-27. doi: 10.1586/17474124.2015.1004312. Epub 2015 Jan 23.

Effects of Mediterranean diet supplemented with silybin-vitamin E-phospholipid complex in overweight patients with non-alcoholic fatty liver disease.

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1
Department of Health Sciences, University "Magna Græcia", Viale Europa - Germaneto, 88100 Catanzaro, Italy.

Abstract

BACKGROUND:

Non-alcoholic fatty liver disease is the most common liver disease worldwide.

AIM:

The aim of this study is to compare the metabolic effects of the Mediterranean diet versus the diet associated with silybin, phosphatidylcholine and vitamin E complex in overweight patients with non-alcoholic fatty liver disease.

METHODS:

Thirty Caucasian overweight patients were randomized into three groups of 10 (Groups A, B and C). A personalized Mediterranean diet was started in Group A and B patients. In association with the diet, Group B patients were given Realsil complex, daily, for 6 months. Group C patients refused any treatment.

RESULTS:

We showed that the Mediterranean diet alone, or in association with the Realsil complex, led to the significant variation in BMI, waist circumference, total cholesterol and triglycerides. We also observed a statistically significant decrease in homeostasis model assessment technique in Group B patients.

KEYWORDS:

BMI; antioxidant; insulin resistance; liver steatosis; metabolism

PMID:
25617046
DOI:
10.1586/17474124.2015.1004312
[Indexed for MEDLINE]

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