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Technol Cancer Res Treat. 2016 Feb;15(1):159-62. doi: 10.1177/1533034614566923. Epub 2015 Jan 23.

Regarding the Credibility of Data Showing an Alleged Association of Cancer with Radiation from CT Scans.

Author information

1
Falcon Analytics, Karney Shomron, Israel socol@falconanalytics.com.
2
Department of Radiation Oncology, Stritch School of Medicine - Loyola University Chicago, Maywood, IL, USA.

Abstract

Computed tomography (CT) scans are of high clinical value as a diagnostic technique, and new applications continue to be identified. However, their application is challenged by emerging concerns regarding carcinogenesis from their radiation. Recent articles made a significant contribution to the above-mentioned concerns by reporting evidence for direct association of the radiation from CT scans with cancer. Such interpretation of the data has already been criticized; there is the possibility of reverse causation due to confounding factors. Nevertheless, such work has had a high impact, with one article being cited more than 300 times from the Web of Science Core Collection within 2 years. However, the data points on cancer relative risk versus CT dose in that article fit straight lines corresponding to the linear no-threshold hypothesis suspiciously well. Here, by applying rigorous statistical analysis, it is shown that the probability of the fit truly being that good or better is only 2%. The results of such studies therefore appear "too good to be true" and the credibility of their conclusions must be questioned.

KEYWORDS:

CT; LNT hypothesis; carcinogenesis; hypothesis testing; radiation; statistics

PMID:
25616624
DOI:
10.1177/1533034614566923
[Indexed for MEDLINE]

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