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Epilepsy Res. 2015 Feb;110:26-31. doi: 10.1016/j.eplepsyres.2014.11.016. Epub 2014 Nov 24.

Dynamic preictal relations in FCD type II: potential for early seizure detection in focal epilepsy.

Author information

1
Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: yosuke.sato@sickikids.ca.
2
Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada; Neuroscience & Mental Health Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada; Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada; Department of Psychology, University of Toronto, Toronto, Ontario, Canada. Electronic address: sam.doesburg@sickkids.ca.
3
Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada; Neuroscience & Mental Health Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada. Electronic address: simeon.wong@sickkids.ca.
4
Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: ayako.ochi@sickkids.ca.
5
Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: hiroshi.otsubo@sickkids.ca.

Abstract

In focal epilepsy, power imbalance between spike-related high frequency oscillations (HFOs) with 80-200 Hz and post-spike slow waves (PSS) in the spike and slow waves selectively occurs within the seizure onset zone (SOZ) before seizure onset. The aim of this study was to elucidate when this preictal power imbalance could occur in the SOZ. We analyzed intracranial EEG data from 6 patients with focal cortical dysplasia. During preictal 3-min period, which was divided into three intervals: 0-1 min, 1-2 min 2-3 min before seizure onset, we performed correlation (Spearman's coefficient) and simple linear regression analyses comparing power of spike-related HFOs and PSS. We analyzed 719 ± 57 (mean ± SD) spike and slow waves per patient, which were obtained from three seizures. In the SOZ, the positive correlation between spike-related HFO and PSS power was drastically reduced during preictal 3-min period, and the slope of regression line (ΔPSS power/ΔHFO power) decreased significantly during 0-1 min before seizure onset (p < 0.05, Steel-Dwass test). The present results indicate that the preictal dynamics of HFO and PSS power in the SOZ may have utility for early seizure detection.

KEYWORDS:

Epilepsy; High-frequency oscillations; Post-spike slow waves; Preictal period; Seizure prediction; Spike and slow wave

[Indexed for MEDLINE]

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