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Gen Comp Endocrinol. 2015 Sep 15;221:255-66. doi: 10.1016/j.ygcen.2014.11.021. Epub 2015 Jan 20.

Insulin/IGF signaling and its regulation in Drosophila.

Author information

1
Department of Zoology, Stockholm University, S-10691 Stockholm, Sweden. Electronic address: dnassel@zoologi.su.se.
2
Department of Zoology, Stockholm University, S-10691 Stockholm, Sweden.

Abstract

Taking advantage of Drosophila as a genetically tractable experimental animal much progress has been made in our understanding of how the insulin/IGF signaling (IIS) pathway regulates development, growth, metabolism, stress responses and lifespan. The role of IIS in regulation of neuronal activity and behavior has also become apparent from experiments in Drosophila. This review briefly summarizes these functional roles of IIS, and also how the insulin producing cells (IPCs) are regulated in the fly. Furthermore, we discuss functional aspects of the spatio-temporal production of eight different insulin-like peptides (DILP1-8) that are thought to act on one known receptor (dInR) in Drosophila.

KEYWORDS:

Drosophila melanogaster; Insulin; Insulin-like peptides

PMID:
25616197
DOI:
10.1016/j.ygcen.2014.11.021
[Indexed for MEDLINE]

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