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Biol Blood Marrow Transplant. 2015 Jul;21(7):1258-65. doi: 10.1016/j.bbmt.2015.01.010. Epub 2015 Jan 20.

Allogeneic Hematopoietic Cell Transplantation for Children with Sickle Cell Disease Is Beneficial and Cost-Effective: A Single-Center Analysis.

Author information

1
Department of Pediatrics, Columbia University Medical Center, New York, New York. Electronic address: sa2812@columbia.edu.
2
Mailman School of Public Health, Columbia University Medical Center, New York, New York.
3
Department of Pediatrics, Columbia University Medical Center, New York, New York.

Abstract

Limited data exist regarding health care utilization (HCU) in patients receiving allogeneic hematopoietic cell transplantation (alloHCT) for sickle cell disease. Financial data from 2002 to 2011 were analyzed for 26 alloHCT patients and 48 control subjects (referred but without alloHCT). HCU of alloHCT was determined over 3 time periods: pre-alloHCT, during alloHCT (day 0 to day +365), and post-alloHCT. The median total cost per patient during the alloHCT year was $413,000 inpatient and $18,000 outpatient. Post-alloHCT HCU decreased when compared with pre-alloHCT and control subjects. The median cost of post-alloHCT outpatient visits per patient was significantly less when compared with pre-alloHCT (P = .044). The median cost of post-alloHCT inpatient visits per patient approached significance when compared with those pre-alloHCT (P = .079). Sixteen post-alloHCT patients, 19 control subjects, and 14 unaffected siblings were surveyed using Pediatric Quality of Life Inventory and EuroQOL questionnaires; however, the questionnaire scores across all 3 patient groups were not statistically significant (P = .2638). When adjusted for health-related quality of life, the analysis suggested alloHCT has a positive impact on health-related quality of life over control subjects. These pilot data support our hypothesis that alloHCT in children with sickle cell disease reduces HCU compared with control subjects without alloHCT.

KEYWORDS:

Cost; Outcomes; Pediatric; Quality of life; Sickle cell disease; Transplant

PMID:
25615608
PMCID:
PMC5605133
DOI:
10.1016/j.bbmt.2015.01.010
[Indexed for MEDLINE]
Free PMC Article

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