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Nat Rev Drug Discov. 2015 Feb;14(2):111-29. doi: 10.1038/nrd4510. Epub 2015 Jan 23.

The re-emergence of natural products for drug discovery in the genomics era.

Author information

1
1] Research and Innovation Support, Dublin City University, Dublin 9, Ireland. [2] Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4 0NR, UK.
2
Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4 0NR, UK.
3
Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia.

Abstract

Natural products have been a rich source of compounds for drug discovery. However, their use has diminished in the past two decades, in part because of technical barriers to screening natural products in high-throughput assays against molecular targets. Here, we review strategies for natural product screening that harness the recent technical advances that have reduced these barriers. We also assess the use of genomic and metabolomic approaches to augment traditional methods of studying natural products, and highlight recent examples of natural products in antimicrobial drug discovery and as inhibitors of protein-protein interactions. The growing appreciation of functional assays and phenotypic screens may further contribute to a revival of interest in natural products for drug discovery.

PMID:
25614221
DOI:
10.1038/nrd4510
[Indexed for MEDLINE]
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