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Gac Sanit. 2015 Jul-Aug;29(4):308-15. doi: 10.1016/j.gaceta.2014.12.003. Epub 2015 Jan 19.

Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design.

Collaborators (570)

Alonso MT, Amiano P, Arias C, Azpiri M, Benavente Y, Boldo E, Bueno A, Bustamante M, Caballero FJ, Campo E, Cantón R, Capelo R, Carmona C, Casabonne D, Chirlaque MD, Cirac J, Clofent J, Colado E, Costas L, Crous M, del Campo R, Santos MD, Dierssen-Sotos T, Ederra M, Espinosa A, Cabrera MF, Somoano AF, Villa TF, García-Esquinas EG, Martín PG, Gómez-Acebo I, Puga CG, Gràcia E, Eslava MG, Guinó E, Huerta JM, Lope V, López-Abente G, Lopez-Otín C, Argüelles BM, Salas SM, Pozo BM, de la Torre AJ, Moreno E, Iribas CM, Olea N, Gelis GO, Paré L, Porta M, Puig M, del Fresno MR, Robles C, Suarez MM, Romero B, Castillo AI, Serra MS, Trejo DS, Santaballa A, Santibáñez M, Sierra Á, Souto A, Villanueva CM, Carrasco E, Sabaté Y, Persavento C, García M, Carrasco G, Expósito A, Andreu M, Bessa X, Piracés M, Lorente JA, Tusquets I, Collet I, Bory F, Pera M, Abella E, Garcia F, Salar A, Piñol M, Fernandez-Llamazares J, Martín MV, Garsot E, Servio LI, Arzoz M, Suarez L, Ruiz JM, Castells A, Serradesanferm A, Bosch A, Muñoz M, Fontanillas M, Alcaraz A, Mengual L, Duran E, Izard C, López C, Benítez JM, Massanes AB, Ferrer OG, Almeda J, Sarret S, Rodriguez MA, Valmaseda AB, Liceran M, Petitbó D, Nolla JI, Pérez S, Martínez S, Vilaseca JM, Sebastián L, Quesada P, Sequera G, Barca EG, Domingo-Domenech E, Oliveira A, Alonso E, de la Banda E, Sabater Y, Vergara M, Exposito A, Alonso T, Padrol I, Klaustermeier J, Florencia Y, Camon V, Esteban A, Campo E, Aymerich M, Lopez-Otin C, Muñoz A, Torralba Y, Dot D, Mercadal S, Sarra J, Padrol I, Medina P, Atienza C, Biondo S, de Oca J, Ferran L, Rodriguez-Moranta F, Soriano A, Guardiola J, Urruticoechea A, Galan M, Capelo R, Santos MD, Banda JM, Zumel Á, Saez A, Garrido JA, Lacasaña M, Ariza JL, García T, García MÁ, Hidalgo MÁ, Asuero M, Bayo J, Vázquez VC, Franco F, Gurucelain JL, Frías MJ, Van de Haar R, Viñas J, Jiménez H, Aguayo M, Pereira A, Gutiérrez SP, Rada R, Candón J, Domínguez J, Ramos M, Pedraza G, Braulio J, Salas J, Labrero D, Muñoz D, Barrero F, Delgado S, Galisteo L, Camacho A, Elena H, Caballero J, Muñoz MJ, Arredondo F, Linares R, Tejada A, Tinto H, Asuero M, Alés JD, Franco F, Coronado MV, Bernal ML, Ortiz JL, Ocaña MN, Martín PG, Cavanillas AB, Miguel, Mejías EJ, Abril OM, Requena RO, Morata JL, Echezarreta EG, López LM, Martínez MM, Sedano PP, de la Pedraja Pavón A, Chirlaque MD, Huerta JM, López-Rojo C, Mendiola J, Pellicer E, Caparrós JM, Oltra EG, Martínez JM, Molina A, Villanueva V, Miranda MJ, Abril C, Martinez J, Salas D, Santaballa A, Ruiz JL, Clofent J, Ponce M, Noos P, Cervera J, del Val A, Segura A, Jiménez N, Bellmunt E, Aznar I, Ramos D, Montón T, Solera MC, Mora EM, Estañ N, Camarasa N, Solanas JV, Ripoll J, Cantero J, Díaz CA, Somoano AF, García AS, Avellón SM, Neumann M, González MJ, Suárez MM, Fernández G, Argüelles BM, Colado E, Fresno MR, Gómez A, Garín U, de Gros A, Tamayo E, Rua M, Lasarte CS, Jauregi M, Recio J, Fernández M, Múgica M, Ciria JP, Guimón E, Adúriz C, Lacasta A, Francisco JS, Alvarez I, Enriquez-Navascués JM, Ruiz I, Michelena M, Alberro JA, Almansa AM, Goñi LM, Elizagaray MI, Técnico MO, Pérez RB, De Miguel Medina MC, Repáraz Romero M, de Azúa Ciria AY, Díaz MM, Lizárraga MS, Jiménez YL, López CE, Legaz SO, Lezaun RA, Hurtado HO, De Miguel Velasco M, Rubio PA, Cunchillos FD, de Liaño Arguelles ÁD, Peñuela JM, Dorronsoro ML, Celaya FB, García DR, de la Higuera Carnicer BG, Tricas JM, Rivera EM, García FV, Noain JJ, Erdozain EA, Ulibarrena CI, Lopeandía JG, Caden MA, Moraza FA, Domench JJ, Arteaga AA, Navarro KA, del Burgo Tajadura Ma, Irastorza FC, Urrisarri MJ, Zubicoa BF, Lorente PG, Sevilla PH, Echamendi ML, Díaz ÁM, Salaverri JM, Gorricho FJ, del Valle MP, de Prado Marcilla J, GarcésDucar M, Herce PA, Barasoain JE, Campos IA, Vergara EA, Beraza BC, Blasco LF, Díaz LG, Larrañeta JG, Ruiz NG, García JG, Orduna MS, Larena DI, Fernández MP, de Ciriza Pejenaute FJ, Escuin R, Puertas IR, Samper IA, Sesma ME, López MJ, Apestegui CZ, Linares C, Cervantes M, Ferreras E, García-Pérez J, Fernández-Navarro P, Pastor R, Ramis R, González Á, Ruiz T, Muñoz V, Delgado R, Lanza M, Marín M, Posada M, Cosmen J, Villanueva A, Castaño A, Jiménez JA, Navarro C, Rin A, Díaz G, Herreros M, Pedraza V, López P, de la Fuente M, de Castro MF, Sobrino J, Calvo R, Carrascal I, Bernal R, Mateo A, García-Olmo D, Zarazaga A, Gombau MÁ, Díaz J, Gómez T, Sánchez T, de la Quintana P, Ordás J, Cuevas P, Sánchez-Pastor M, de la Peña JJ, Tabernero Á, Cámara N, Hardisson D, Suárez A, Burgos E, Alves J, Miguel M, Feliú J, Belda C, Zamora P, Sánchez A, Hernández A, Beato T, Arroba A, Ballesteros A, Canora S, García C, López P, Romero M, José TS, Espinel M, Mañas A, Sánchez M, Ramón H, Morillo JL, Cuchí M, García MJ, Ramos JM, Rojo R, Sanjuanbenito A, Villanueva AG, Gras M, Cabañas JL, Collado V, Arano I, Capela I, Mojarrieta C, Peñas B, Rodríguez M, Ramos A, Sancho S, Hervás A, Moreno P, Sánchez C, DoloresRubio, López MJ, Montoya L, Sancho P, Rodríguez L, Durán E, Morel S, Burgos J, García R, del Cañizo CG, Díaz A, González F, Cristóbal E, Barahona C, García R, Vázquez S, Esteban V, Pedrera M, Martínez J, Carrato A, Ponce CG, Santos-Olmo A, Barrientos RR, López G, Fernández A, García AB, Noriega A, Campo M, Varona E, López F, Montero M, Gómez MT, Bartibas P, Sanz R, Montes T, Salinero MÁ, Herrero M, Igea M, Calvo C, Rodríguez M, Pérez-Pellón C, Maestre M, Agora MA, Martín MG, Velázquez D, Fernández B, Castro M, Ayuso E, Masa R, Antelo C, García S, Herrero S, Delgado A, Vilardell L, Puig-Vives M, Osca-Gelis G, Buxo M, Izquierdo A, Carmona-Garcia MC, Romanos RR, Galindo CT, Bargalló PM, Sanchez ER, Saez M, Marcos-Gragera R, Roncero JM, Gallardo D, Coll R, Blanco I, Ruano LM, Castaño EA, Rusiñol JM, Perez RJ, Pujol IM, Tuero GC, de Barrio Lera JP, Carral JM, Pérez CA, Puente ME, Balbuena SP, Presa JM, Ramírez JA, Martínez AÁ, de Francisco TG, Elosua TG, Teso EP, Fueyo JF, Guadarrama OA, Turienzo Frade Mdel A, De la Hoz Riesco M, Fernández JJ, Fernández VS, Fernández RC, Santamaría MV, Simón JA, Ganso AM, Pacho AV, Alegre SV, Plaza FJ, Cuenllas BÁ, Franco EH, Martín MH, Ariño MT, Tascón CD, Palomo JA, Castañón López Mdel C, Lorenzo MP, González IA, Rivero FG, Román CH, Fernández EÁ, Bayón TR, Fernández AG, Municio F, de Celis MG, García MJ, Ingelmo LÁ, Herrero JG, Carbajo MJ, Esteras TR, Baz BV, Baticón CH, Baza EÁ, Urdiales AU, Gil JI, López MA, Ule EC, Diez CB, Marín AI, Bernabeu MÁ, de Abajo Olea S, Rojo CV, Fernández MÁ, González FG, Martínez LG, del HuertoTrancón Moratiel M, Ramos NC, Fidalgo SP, Pérez S, Coque PR, González ÁG, Díez AB.

Abstract

INTRODUCTION:

We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors.

METHODS:

Between 2008-2013, 10,106 subjects aged 20-85 were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,112 cases with a new diagnosis of prostate cancer, 1,738 of breast cancer, 2,140 of colorectal cancer, 459 of gastro-oesophageal cancer, 559 cases with chronic lymphocytic leukaemia and 4,098 population controls frequency matched to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects.

DISCUSSION:

This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.

KEYWORDS:

Breast cancer; Case-control; Caso-control; Chronic lymphocytic leukemia; Colorectal cancer; Cáncer colorrectal; Cáncer de mama; Cáncer de próstata; Cáncer gástrico; Epidemiology; Epidemiología; Gastric cancer; Leucemia linfática crónica; Prostate cancer

PMID:
25613680
DOI:
10.1016/j.gaceta.2014.12.003
[Indexed for MEDLINE]
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