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Neuron. 2015 Jan 21;85(2):233-5. doi: 10.1016/j.neuron.2014.12.062.

Striking the right balance: cortical modulation of the subthalamic nucleus-globus pallidus circuit.

Author information

1
Center of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
2
Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address: agittis@cmu.edu.

Abstract

The subthalamic nucleus-globus pallidus network is a potential source of oscillations in Parkinson's disease, but the mechanism is unknown. In this issue of Neuron, Chu et al. (2015) present a cortically driven form of heterosynaptic plasticity that could promote oscillatory activity after dopamine depletion.

PMID:
25611504
DOI:
10.1016/j.neuron.2014.12.062
[Indexed for MEDLINE]
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