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J Gastroenterol Hepatol. 2015 Jun;30(6):970-6. doi: 10.1111/jgh.12900.

Interleukin-8: A critical chemokine in biliary atresia.

Author information

1
Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China; Key Laboratory of Neonatal Disease, Ministry of Health, Shanghai, China.

Abstract

Biliary atresia (BA) is characterized by periductular inflammation and fibrosis and is associated with the progressive obliteration of the bile ducts. The induction and maintenance of systemic and local inflammatory responses plays a pivotal role in this process. Interleukin-8 (IL-8) is an important mediator of inflammation and the immune response in human disease. IL-8 is overexpressed in BA, and its expression positively correlates with inflammation and liver fibrosis. In this review, we focus on the available evidence, recent insights, and future clinical and preclinical possibilities regarding the role of IL-8 in BA.

KEYWORDS:

biliary atresia; inflammation; interleukin-8; liver fibrosis; signaling

PMID:
25611432
DOI:
10.1111/jgh.12900
[Indexed for MEDLINE]

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