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Oncoimmunology. 2014 Jul 3;3(7):e950166. eCollection 2014.

Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings.

Author information

1
Department of Biological Sciences; Middle East Technical University ; Ankara, Turkey.
2
Department of Molecular Biology and Genetics Bilkent University ; Ankara, Turkey.

Abstract

Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications. We recently described a simple strategy to convert a Toll-like receptor 9 (TLR9) agonist devoid of interferon α (IFNα) stimulating activity into a robust Type I interferon inducer with potent vaccine adjuvant activity.

KEYWORDS:

CpG ODN; Type I interferon; vaccine adjuvant

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