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J Neurosci. 2015 Jan 21;35(3):1319-34. doi: 10.1523/JNEUROSCI.3989-14.2015.

Synaptic consolidation: from synapses to behavioral modeling.

Author information

1
School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne EPFL, Switzerland.
2
School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne EPFL, Switzerland wulfram.gerstner@epfl.ch.

Abstract

Synaptic plasticity, a key process for memory formation, manifests itself across different time scales ranging from a few seconds for plasticity induction up to hours or even years for consolidation and memory retention. We developed a three-layered model of synaptic consolidation that accounts for data across a large range of experimental conditions. Consolidation occurs in the model through the interaction of the synaptic efficacy with a scaffolding variable by a read-write process mediated by a tagging-related variable. Plasticity-inducing stimuli modify the efficacy, but the state of tag and scaffold can only change if a write protection mechanism is overcome. Our model makes a link from depotentiation protocols in vitro to behavioral results regarding the influence of novelty on inhibitory avoidance memory in rats.

KEYWORDS:

consolidation; modeling; synaptic tagging

PMID:
25609644
PMCID:
PMC6605543
DOI:
10.1523/JNEUROSCI.3989-14.2015
[Indexed for MEDLINE]
Free PMC Article

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