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Sci Transl Med. 2015 Jan 21;7(271):271ps1. doi: 10.1126/scitranslmed.3010473.

Cancer and the gut microbiota: an unexpected link.

Author information

1
Gustave Roussy Comprehensive Cancer Center, F-94805 Villejuif, France. INSERM, U1015, CICBT507, F-94805 Villejuif, France. laurence.zitvogel@gustaveroussy.fr.
2
Gustave Roussy Comprehensive Cancer Center, F-94805 Villejuif, France. Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, F-75006 Paris, France. Université Paris Descartes/Paris V, Sorbonne Paris Cité, F-75006 Paris, France. INSERM, U1138, F-75006 Paris, France.
3
Gustave Roussy Comprehensive Cancer Center, F-94805 Villejuif, France. INSERM, U1015, CICBT507, F-94805 Villejuif, France.
4
Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
5
Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, F-75006 Paris, France. Université Paris Descartes/Paris V, Sorbonne Paris Cité, F-75006 Paris, France. INSERM, U1138, F-75006 Paris, France. Pôle de Biologie, Hôpital Européen Georges Pompidou F-75015, AP-HP, Paris, France. Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Center, F-94805 Villejuif, France.

Abstract

Changes in the interactions among the gut microbiota, intestinal epithelium, and host immune system are associated with many diseases, including cancer. We discuss how environmental factors infuence this cross-talk during oncogenesis and tumor progression and how manipulations of the gut microbiota might improve the clinical activity of anticancer agents.

PMID:
25609166
PMCID:
PMC4690201
DOI:
10.1126/scitranslmed.3010473
[Indexed for MEDLINE]
Free PMC Article

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