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Nat Commun. 2015 Jan 22;6:5942. doi: 10.1038/ncomms6942.

Osmotic pressure induced tensile forces in tendon collagen.

Author information

1
Department of Biomaterials, Max Planck Institute for Colloids and Interfaces, Research Campus Golm, 14424 Potsdam, Germany.
2
Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, MIT, Cambridge, Massachusetts 02139, USA.

Abstract

Water is an important component of collagen in tendons, but its role for the function of this load-carrying protein structure is poorly understood. Here we use a combination of multi-scale experimentation and computation to show that water is an integral part of the collagen molecule, which changes conformation upon water removal. The consequence is a shortening of the molecule that translates into tensile stresses in the range of several to almost 100 MPa, largely surpassing those of about 0.3 MPa generated by contractile muscles. Although a complete drying of collagen would be relevant for technical applications, such as the fabrication of leather or parchment, stresses comparable to muscle contraction already occur at small osmotic pressures common in biological environments. We suggest, therefore, that water-generated tensile stresses may play a role in living collagen-based materials such as tendon or bone.

PMID:
25608644
PMCID:
PMC4354200
DOI:
10.1038/ncomms6942
[Indexed for MEDLINE]
Free PMC Article

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