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Cancer Invest. 2015 Mar;33(2):39-40. doi: 10.3109/07357907.2014.998836.

The association between NQO1 Pro187Ser polymorphism and urinary system cancer susceptibility: a meta-analysis of 22 studies.

Author information

1
Department of Medical Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University , Kunshan, Jiangsu , China ,1.

Abstract

Numerous studies have investigated the association between NQO1 Pro187Ser polymorphism and urinary system cancer risk, but the findings are inconsistent. To derive a more precise estimation of such association, we performed a meta-analysis based on 22 publications encompassing 5,274 cases and 6,459 controls. Overall, significant association was found between NQO1 Pro187Ser polymorphism and urinary system cancer risk. Moreover, stratified analysis observed a statistically significant association for bladder cancer, prostate cancer, renal cell carcinoma, Caucasians, Asians, and hospital-based studies. In summary, this meta-analysis indicated that NQO1 Pro187Ser polymorphism conferred genetic susceptibility to urinary system cancer.

KEYWORDS:

Cancer susceptibility; Meta-analysis; NQO1; Polymorphism

PMID:
25608636
DOI:
10.3109/07357907.2014.998836
[Indexed for MEDLINE]

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