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Biochem Cell Biol. 2015 Oct;93(5):479-86. doi: 10.1139/bcb-2014-0107. Epub 2014 Dec 1.

Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies.

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a Department of Pharmacology & Therapeutics, Faculty of Health Sciences, University of Manitoba, Manitoba Institute of Child Health, 501C John Buhler Research Center, 715 McDermot Avenue, Winnipeg, MB, R3E 0P4, Canada.
b Department of Pharmacology, Norman Bethune Medical College, Jilin University, Changchun 130021, China.
c Department of Biochemistry and Medical Genetics, Faculty of Health Sciences, University of Manitoba, DREAM Theme, Manitoba Institute of Child Health, Winnipeg, MB R3E 0T6, Canada.


The incidence of type 2 diabetes is increasing rapidly worldwide, and the development of novel anti-diabetic drugs is emerging. However, most anti-diabetic drugs cannot be used in patients with hepatic dysfunction, renal disease, and heart disease, which makes pharmacological therapy of type 2 diabetes complicated. Despite continued introduction of novel agents, the search for an ideal drug that is useful as both a hypoglycemic agent and to reduce diabetes-related complications remains elusive. Berberine is an isoquinoline alkaloid extract that has shown promise as a hypoglycemic agent in the management of diabetes in animal and human studies. Mechanistic studies have revealed beneficial effects of berberine on diabetes-related complications. Although there have been few clinical reports of the anti-diabetic effects of berberine, little documentation of adverse effects in humans positions it as a potential candidate drug to treat type 2 diabetes. In the present review, the anti-diabetic mechanism of berberine, its effect on diabetes-related complications, and its recent use in human clinical studies is highlighted. In addition, we summarize the different treatments for type 2 diabetes in adults and children.


adenosine-5′-monophosphate kinase; adults; berberine; berbérine; children; complications; diabète sucré de type 2; drug; enfants; hypoglycemic; hypoglycémiant; metabolism; médicament; métabolisme; type 2 diabetes mellitus

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