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Rev Bras Ginecol Obstet. 2015 Jan;37(1):30-5. doi: 10.1590/SO100-720320140005134.

[Prevalence of low bone mineral density in postmenopausal breast cancer survivors].

[Article in Portuguese]

Author information

1
Programa de Pós-Graduação em Ginecologia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brasil.
2
Curso de Graduação em Medicina, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brasil.
3
Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brasil.

Abstract

PURPOSE:

To evaluate the prevalence of low bone mineral density (BMD) in postmenopausal breast cancer survivors.

METHODS:

In this cross-sectional study, 115 breast cancer survivors, seeking healthcare at a University Hospital in Brazil, were evaluated. Eligibility criteria included women with amenorrhea ≥ 12 months and age ≥ 45 years, treated for breast cancer and metastasis-free for at least five years. BMD was measured by DEXA at the lumbar spine (L1-L4) and femoral neck. Low BMD was considered when total-spine and/or femoral-neck T-score values were <-1.0 Delphi Score (DP) (osteopenia and osteoporosis). The risk factors for low BMD were assessed by interview. Data were analyzed statistically by the χ(2) test and Fisher's exact test.

RESULTS:

The mean age of breast cancer survivors was 61.6 ± 10.1 years and time since menopause was 14.2 ± 5.6 years, with a mean follow-up of 10.1 ± 3.9 years. Considering spine and femoral neck, 60% of breast cancer survivors had low BMD. By evaluating the risk factors for low BMD, a significant difference was found in the percent distribution for age (higher % of women >50 years with low BMD), personal history of previous fracture (11.6% with low BMD versus 0% with normal BMD) and BMI. A higher frequency of obesity was observed among women with normal BMD (63%) compared to those with low BMD (26.1%) (p<0.05).

CONCLUSION:

Postmenopausal breast cancer survivors had a high prevalence of osteopenia and osteoporosis.

PMID:
25607127
DOI:
10.1590/SO100-720320140005134
[Indexed for MEDLINE]

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