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Joints. 2014 Mar 21;1(4):167-70. eCollection 2013 Oct-Dec.

The treatment of chondral lesions of the knee with the microfracture technique and platelet-rich plasma.

Author information

1
Department of Orthopaedics, University of Sassari, Italy.

Abstract

PURPOSE:

to assess the efficacy of associating the microfracture technique with platelet-rich plasma (PRP) injections in the treatment of chondral lesions to promote acceleration and optimization of the healing process compared with the traditional microfracture approach.

METHODS:

from September 2011 to August 2012, 20 patients (9 males and 11 females, aged 30-55 years) were treated. All presented with chondral lesions of the medial femoral condyle of the knee and a pain duration ranging from 8 to 12 months. The patients were randomized into two groups (A and B). Group A was treated with the microfracture technique and a total of three intra-articular injections of PRP. Group B was treated with microfractures alone. Clinical follow-up was performed at 3, 6 and 12 months after treatment. Clinical function was assessed on the basis of the International Knee Documentation Committee (IKDC) score. Pain was evaluated using a visual analogue scale (VAS).

RESULTS:

the patients in group A had a mean baseline IKDC score of 31.2, which rose to 84.2 at 12 months. The IKDC scores in group B were at 30.1 at baseline and 81 at 12 months.

CONCLUSIONS:

the results of our study suggest that functional recovery and resolution of pain are obtained more quickly in PRP-treated patients. We also observed a better functional outcome in the patients treated with the combination of PRP and microfractures, even at 12 months, although the difference was not statistically significant.

LEVEL OF EVIDENCE:

level II, randomized clinical study.

KEYWORDS:

cartilage regeneration; chondral lesions; microfracture; platelet-rich plasma

PMID:
25606529
PMCID:
PMC4295714

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