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World J Plast Surg. 2015 Jan;4(1):23-8.

The healing effect of nettle extract on second degree burn wounds.

Author information

1
Department of Plastic Surgery, Iran University of Medical Sciences, Tehran, Iran;
2
Department of Plastic and Reconstructive Surgery, Burn Research Center, Hazrat Fatima Hospital, Iran University of Medical Sciences, Tehran, Iran.
3
Department of Pathology, Kerman University of Medical Sciences, Kerman, Iran;
4
Department of Plastic Surgery, Kerman University of Medical Sciences, Kerman, Iran;
5
Department of Surgery, Iran University of Medical Sciences, Tehran, Iran;
6
Department of Surgery and Radiology, Faculty of Veterinary, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

Numerous studies were carried out to develop more sophisticated dressings to expedite healing processes and diminish the bacterial burden in burn wounds. This study assessed the healing effect of nettle extract on second degree burns wound in rats in comparison with silver sulfadiazine and vaseline.

METHODS:

Forty rats were randomly assigned to four equal groups. A deep second-degree burn was created on the back of each rat using a standard burning procedure. The burns were dressed daily with nettle extract in group 1, silver sulfadiazine in group 2, vaseline in group 3 and without any medication in group 4 as control group. The response to treatment was assessed by digital photography during the treatment until day 42. Histological scoring was undertaken for scar tissue samples on days 10 and 42.

RESULTS:

A statistically significant difference was observed in group 1 compared with other groups regarding 4 scoring parameters after 10 days. A statistically significant difference was seen for fibrosis parameter after 42 days. In terms of difference of wound surface area, maximal healing was noticed at the same time in nettle group and minimal repair in the control group.

CONCLUSION:

Our findings showed maximal rate of healing in the nettle group. So it may be a suitable substitute for silver sulfadiazine and vaseline when available.

KEYWORDS:

Burn; Healing; Nettle; Rat; Silver sulfadiazine; Vaseline; Wound

PMID:
25606473
PMCID:
PMC4298861

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