Format

Send to

Choose Destination
Invest Ophthalmol Vis Sci. 2015 Jan 20;56(2):1089-96. doi: 10.1167/iovs.14-14973.

Cyclocoagulation of the ciliary bodies by high-intensity focused ultrasound: a 12-month multicenter study.

Author information

1
Hôpital de la Croix-Rousse, Service d'Ophtalmologie, Hospices Civils de Lyon, Lyon, France.
2
Service d'Ophtalmologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France.
3
Service d'Ophtalmologie, Hôpital Claude Huriez, CHRU de Lille, Lille, France.
4
Service d'Ophtalmologie 3, Centre Hospitalier National des Quinze-Vingts, Paris, France.
5
Institut du Glaucome, Fondation Hôpital Saint-Joseph, Paris, France.
6
Service d'Ophtalmologie, Hôpital d'Instruction des Armées du Val de Grâce, Paris, France.
7
Centre Ophtalmologique Kléber, Lyon, France.
8
Service d'Ophtalmologie 2, Centre Hospitalier National des Quinze-Vingts, Paris, France.
9
Service d'Ophtalmologie, Hôpital Général, Dijon, France.

Abstract

PURPOSE:

To evaluate the safety and efficacy of high-intensity focused ultrasound (HIFU) cyclocoagulation in reducing intraocular pressure (IOP) in patients with refractory glaucoma by using a novel miniaturized delivery device (EyeOP1).

METHODS:

We conducted a 12-month open-label multicenter prospective study (EyeMUST1 Study). Patients with primary (primary open-angle glaucoma [POAG]) or secondary refractory glaucoma were treated in two groups depending on the duration of each ultrasound shot (group 1: 4 seconds; group 2: 6 seconds). The primary efficacy outcome was based on IOP reduction at 6 and 12 months.

RESULTS:

Fifty-two patients were enrolled: 36 (69%) had POAG and 16 (31%) had secondary glaucoma. Group 1 (n = 24) and group 2 (n = 28) had similar demographics and baseline characteristics. In group 1, IOP was reduced from a mean preoperative value of 29.7 ± 7.7 mm Hg (n = 3.5 glaucoma medications) to a mean postoperative value of 21.3 ± 6.7 mm Hg (n = 3.5 glaucoma medications) and 20.1 ± 6.7 mm Hg (n = 3.2 glaucoma medications) at 6 and 12 months, respectively. In group 2, IOP was reduced from a mean preoperative value of 29.0 ± 7.4 mm Hg (n = 3.3 glaucoma medications) to a mean postoperative value of 20.2 ± 7.4 mm Hg (n = 3.4 glaucoma medications) and 18.5 ± 6.6 mm Hg (n = 3.5 glaucoma medications) at 6 and 12 months, respectively. At 12 months, the IOP reduction was sustained in both groups (32% IOP reduction in group 1 and 36% IOP reduction in group 2). The overall tolerance of the technique was good, with no serious adverse events.

CONCLUSIONS:

The new miniaturized HIFU EyeOP1 delivery device seems to be effective in decreasing IOP in patients with refractory glaucoma. The technology offers a good safety profile. (ClinicalTrials.gov number, NCT01338467.).

KEYWORDS:

ciliary body; methods, treatment outcome; therapy, intraocular pressure, miniaturization; ultrasonography, glaucoma

PMID:
25604688
DOI:
10.1167/iovs.14-14973
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center