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Invest Ophthalmol Vis Sci. 2015 Jan 20;56(2):914-7. doi: 10.1167/iovs.14-16102.

Temporal summation in children with a history of retinopathy of prematurity.

Author information

1
Department of Ophthalmology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States.

Abstract

PURPOSE:

To assess temporal summation in children with a history of retinopathy of prematurity (ROP) by determining the critical duration (tCRIT) for complete temporal summation under rod-mediated conditions. From prior ERG studies, it is known that the kinetics of activation of phototransduction are prolonged in the ROP rod photoreceptor.

METHODS:

Dark-adapted thresholds for detecting 10° diameter stimuli with durations from 10 to 640 ms were measured. A two-alternative, spatial, forced-choice psychophysical procedure was used. The tCRIT for complete summation was estimated in former preterm subjects with a history of severe ROP (n = 7), mild ROP (n = 23), and no ROP (n = 15). The subjects ranged in age from 10.4 to 17.6 (median 15.6) years. Age-similar term-born control subjects (n = 5) were also tested.

RESULTS:

Critical duration was significantly longer in subjects with a history of ROP than in subjects who never had ROP or who were born at term. Mean tCRIT in the mild ROP group [127.5 (SD = 19.9) ms] and severe group [147.6 (SD = 18.9) ms] did not differ significantly, but both were significantly longer than in former preterms who never had ROP [101.1 (SD = 16.5) ms] and in term-born controls [101.0 (SD = 19.5) ms].

CONCLUSIONS:

In ROP subjects, tCRIT is significantly prolonged. This is likely due to abnormal kinetics in the rod outer segment.

KEYWORDS:

photoreceptors; psychophysics; retinopathy of prematurity; scotopic visual threshold; temporal summation

PMID:
25604681
PMCID:
PMC4321397
DOI:
10.1167/iovs.14-16102
[Indexed for MEDLINE]
Free PMC Article

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