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Nat Rev Mol Cell Biol. 2015 Feb;16(2):82-94. doi: 10.1038/nrm3934.

Spatiotemporal regulation of the anaphase-promoting complex in mitosis.

Author information

1
Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA.

Abstract

The appropriate timing of events that lead to chromosome segregation during mitosis and cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute to tumorigenesis. Key mitotic regulators are controlled through ubiquitylation and proteasome-mediated degradation. The APC/C (anaphase-promoting complex; also known as the cyclosome) is an E3 ubiquitin ligase that has a crucial function in the regulation of the mitotic cell cycle, particularly at the onset of anaphase and during mitotic exit. Co-activator proteins, inhibitor proteins, protein kinases and phosphatases interact with the APC/C to temporally and spatially control its activity and thus ensure accurate timing of mitotic events.

PMID:
25604195
PMCID:
PMC4386896
DOI:
10.1038/nrm3934
[Indexed for MEDLINE]
Free PMC Article

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