Format

Send to

Choose Destination
Biochem Biophys Res Commun. 2015 Feb 20;457(4):621-6. doi: 10.1016/j.bbrc.2015.01.037. Epub 2015 Jan 17.

MiR-204-5p suppresses cell proliferation by inhibiting IGFBP5 in papillary thyroid carcinoma.

Author information

1
Department of Endocrine, Shanghai Pudong Gongli Hospital, Shanghai 200135, China.
2
Department of Endocrine, Shanghai Pudong Gongli Hospital, Shanghai 200135, China. Electronic address: mjgugonglihos@yeah.net.

Abstract

microRNAs (miRNAs) are frequently dysregulated in human malignancies. It was recently shown that miR-204-5p is downregulated in papillary thyroid carcinoma (PTC); however, the functional significance of this observation is not known. This study investigated the role of miR-204-5p in PTC. Overexpressing miR-204-5p suppressed PTC cell proliferation and induced cell cycle arrest and apoptosis. The results of a luciferase reporter assay showed that miR-204-5p can directly bind to the 3' untranslated region (UTR) of insulin-like growth factor-binding protein 5 (IGFBP5) mRNA, and IGFBP5 overexpression partially reversed the growth-inhibitory effects of miR-204-5p. These results indicate that miR-204-5p acts as a tumor suppressor in PTC by regulating IGFBP5 expression and that miR-204-5p can potentially serve as an antitumorigenic agent in the treatment of PTC.

KEYWORDS:

IGFBP5; Papillary thyroid carcinoma; Proliferation; miR-204-5p

PMID:
25603050
DOI:
10.1016/j.bbrc.2015.01.037
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center