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PLoS One. 2015 Jan 20;10(1):e0116100. doi: 10.1371/journal.pone.0116100. eCollection 2015.

Creating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmission.

Author information

1
Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda.
2
International AIDS Vaccine Initiative (IAVI), New York, New York, United States of America; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America.
3
Zambia-Emory HIV Research Project, Lusaka and Copperbelt, Zambia.
4
Project San Francisco, Kigali, Rwanda.
5
Centre for Geographic Medicine-Coast/KEMRI, Kilifi, Kenya; University of Oxford, Oxford, United Kingdom.
6
Kenya AIDS Vaccine Institute-Institute of Clinical Research, Nairobi, Kenya.
7
Aurum Institute, Rustenburg and Johannesburg, South Africa.
8
Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
9
IAVI-UVRI HIV Vaccine Program, Entebbe and Masaka, Uganda.
10
Emory University, Atlanta, Georgia, United States of America.
11
University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
12
International AIDS Vaccine Initiative (IAVI), New York, New York, United States of America.
13
IAVI, Johannesburg, South Africa.
14
IAVI Human Immunology Laboratory, Imperial College, London, United Kingdom.

Abstract

HIV epidemiology informs prevention trial design and program planning. Nine clinical research centers (CRC) in sub-Saharan Africa conducted HIV observational epidemiology studies in populations at risk for HIV infection as part of an HIV prevention and vaccine trial network. Annual HIV incidence ranged from below 2% to above 10% and varied by CRC and risk group, with rates above 5% observed in Zambian men in an HIV-discordant relationship, Ugandan men from Lake Victoria fishing communities, men who have sex with men, and several cohorts of women. HIV incidence tended to fall after the first three months in the study and over calendar time. Among suspected transmission pairs, 28% of HIV infections were not from the reported partner. Volunteers with high incidence were successfully identified and enrolled into large scale cohort studies. Over a quarter of new cases in couples acquired infection from persons other than the suspected transmitting partner.

PMID:
25602351
PMCID:
PMC4300215
DOI:
10.1371/journal.pone.0116100
[Indexed for MEDLINE]
Free PMC Article

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