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PLoS Biol. 2015 Jan 20;13(1):e1002050. doi: 10.1371/journal.pbio.1002050. eCollection 2015 Jan.

Where next for microbiome research?

Author information

1
Division of Infectious Diseases, Brigham and Women's Hospital, Department of Microbiology and Immunobiology Harvard Medical School and HHMI, Boston, Massachusetts, United States of America.
2
Australian Centre for Ecogenomics and Advanced Water Management Centre, The University of Queensland, Brisbane, Australia.
3
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America; Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America; Santa Fe Institute, Santa Fe, New Mexico, United States of America.
4
Department of Integrative Biology, University of Texas, Austin, Texas, United States of America.
5
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America.
6
Michael Smith Laboratories, University of British Columbia, Vancouver, Canada.
7
Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
8
Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
9
J. Craig Venter Institute, Rockville, Maryland, United States of America.
10
Second Genome, Inc., South San Francisco, California, United States of America.
11
J. Craig Venter Institute, La Jolla, California, United States of America.

Abstract

The development of high-throughput sequencing technologies has transformed our capacity to investigate the composition and dynamics of the microbial communities that populate diverse habitats. Over the past decade, these advances have yielded an avalanche of metagenomic data. The current stage of "van Leeuwenhoek"-like cataloguing, as well as functional analyses, will likely accelerate as DNA and RNA sequencing, plus protein and metabolic profiling capacities and computational tools, continue to improve. However, it is time to consider: what's next for microbiome research? The short pieces included here briefly consider the challenges and opportunities awaiting microbiome research.

PMID:
25602283
PMCID:
PMC4300079
DOI:
10.1371/journal.pbio.1002050
[Indexed for MEDLINE]
Free PMC Article

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