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PLoS One. 2015 Jan 20;10(1):e0115850. doi: 10.1371/journal.pone.0115850. eCollection 2015.

A meta-analysis of high dose, intermittent vitamin D supplementation among older adults.

Author information

1
College of Humanities and Management, Southern Medical University, Guangzhou, Guangdong Province, China.

Abstract

BACKGROUND:

The effects of intermittent, high dose vitamin D treatment in older adults have not been documented. We conducted a meta-analysis to provide a quantitative assessment of the efficiency of intermittent, high dose vitamin D treatment on falls, fractures, and mortality among older adults.

METHODS:

Electronic databases were searched for randomized controlled trials (RCTs) on high dose, intermittent vitamin D supplementation among older adults. Two researchers independently screened the literature according to specified inclusive and exclusive criteria to extract the data. Meta-analysis was performed by using Review Manager 5.1.0 software.

RESULTS:

Nine trials were included in this meta-analysis. High dose, intermittent vitamin D therapy did not decrease all-cause mortality among older adults. The risk ratio (95% CI) was 1.04 (0.91-1.17). No benefit was seen in fracture or fall prevention. The risk ratio for hip fractures (95% CI) was 1.17 (0.97-1.41) while for non-vertebral fractures (95% CI) it was 1.06 (0.91-1.22), and the risk ratio for falls (95% CI) was 1.02 (0.96-1.08). Results remained robust after sensitivity analysis.

CONCLUSION:

Supplementation of intermittent, high dose vitamin D may not be effective in preventing overall mortality, fractures, or falls among older adults. The route of administration of vitamin D supplements may well change the physiological effects.

PMID:
25602255
PMCID:
PMC4300188
DOI:
10.1371/journal.pone.0115850
[Indexed for MEDLINE]
Free PMC Article

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