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Nat Rev Neurosci. 2015 Feb;16(2):79-93. doi: 10.1038/nrn3886.

Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits.

Author information

1
School of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK.
2
Department of Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016, USA.
3
Department of Pathology &Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.

Abstract

The adult mammalian cerebellar cortex is generally assumed to have a uniform cytoarchitecture. Differences in cerebellar function are thought to arise primarily through distinct patterns of input and output connectivity rather than as a result of variations in cortical microcircuitry. However, evidence from anatomical, physiological and genetic studies is increasingly challenging this orthodoxy, and there are now various lines of evidence indicating that the cerebellar cortex is not uniform. Here, we develop the hypothesis that regional differences in properties of cerebellar cortical microcircuits lead to important differences in information processing.

PMID:
25601779
PMCID:
PMC4476393
DOI:
10.1038/nrn3886
[Indexed for MEDLINE]
Free PMC Article

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