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In Vivo. 2015 Jan-Feb;29(1):137-40.

Interferon gamma release assays and tubercolin skin test performance in different settings of HIV immunodeficiency.

Author information

1
Third Department of Infectious Diseases- D. Cotugno Hospital- AORN dei Colli, Naples, Italy rob.parrella@gmail.com.
2
Third Department of Infectious Diseases- D. Cotugno Hospital- AORN dei Colli, Naples, Italy.
3
Unit of Microbiology and Virology- D. Cotugno Hospital- AORN dei Colli, Naples, Italy.

Abstract

BACKGROUND/AIM:

HIV infection is a risk factor for re-activation of latent tubercolosis infection (LTBI). In recent years new blood tests for the detection of TB infection have been developed: Quantiferon TB Gold in Tube and TSPOT TB, which are interferon-γ releasing assays (IGRAs), have improved the identification of LTBI. In our study we have compared IGRAs and TST in HIV-positive patients with different settings of immunodeficiency.

PATIENTS AND METHODS:

98 consecutive HIV patients were recruited. They underwent a blood draw, a chest radiography and a tuberculin skin test. The HIV infection setting was detected and IGRAs were carried-out. Five patients showed a complete correspondence of TST, TSPOT-TB and QFT-IT. Discordant results were observed in patients testing positive to IGRAs but negative to TST. Only 2 patients showed positive TST and negative IGRAs.

CONCLUSION:

Our study showed a poor concordance between tuberculin skin test and IGRAs, mainly in patients with a low CD4 cell count.

KEYWORDS:

HIV infection; Latent tubercolosis infection; interferon gamma releasing assays; tuberculin skin test

PMID:
25600543
[Indexed for MEDLINE]

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