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In Vivo. 2015 Jan-Feb;29(1):1-4.

Curcumin suppression of cytokine release and cytokine storm. A potential therapy for patients with Ebola and other severe viral infections.

Author information

1
SignPath Pharma, Inc., Quakertown, PA, U.S.A.
2
SignPath Pharma, Inc., Quakertown, PA, U.S.A. lhelson@comcast.net.

Abstract

BACKGROUND:

The terminal stage of Ebola and other viral diseases is often the onset of a cytokine storm, the massive overproduction of cytokines by the body's immune system.

MATERIALS AND METHODS:

The actions of curcumin in suppressing cytokine release and cytokine storm are discussed.

RESULTS:

Curcumin blocks cytokine release, most importantly the key pro-inflammatory cytokines, interleukin-1, interleukin-6 and tumor necrosis factor-α. The suppression of cytokine release by curcumin correlates with clinical improvement in experimental models of disease conditions where a cytokine storm plays a significant role in mortality.

CONCLUSION:

The use of curcumin should be investigated in patients with Ebola and cytokine storm. Intravenous formulations may allow achievement of therapeutic blood levels of curcumin.

KEYWORDS:

Curcumin; Ebola; cytokine storm; interleukin-1; interleukin-6; review; tumor necrosis factor-α

PMID:
25600522
[Indexed for MEDLINE]

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