Format

Send to

Choose Destination
Pediatr Blood Cancer. 2015 Jun;62(6):1081-3. doi: 10.1002/pbc.25408. Epub 2015 Jan 16.

Incidental diagnosis of diffuse intrinsic pontine glioma in children.

Author information

1
Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Abstract

Children with diffuse intrinsic pontine glioma (DIPG) have a short onset, rapidly progressive neurologic decline before diagnosis. Therefore, incidental diagnosis of such an aggressive cancer is counterintuitive, yet our experience shows DIPG may occur as part of a spectrum of incidentally diagnosed pediatric brain cancers. Although children with incidentally diagnosed DIPG may experience a longer survival, it remains a potentially deadly cancer despite treatment with radiotherapy. Histologic confirmation is warranted when feasible in such patients to confirm diagnosis. Moreover, recent advances in genome-wide analyses may suggest incidentally diagnosed DIPGs are biologically distinct from the majority of these cancers.

KEYWORDS:

neuro-oncology; pediatric hematology/oncology; tumor biology

PMID:
25598012
PMCID:
PMC4405458
DOI:
10.1002/pbc.25408
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center