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Curr Opin Immunol. 2015 Jun;34:22-7. doi: 10.1016/j.coi.2014.12.009. Epub 2015 Jan 16.

Suppression of antigen presentation by IL-10.

Author information

1
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
2
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address: paul.roche@nih.gov.

Abstract

Regulated antigen presentation to immune cells determines the effectiveness of an immune response. IL-10 is an immunosuppressive cytokine that regulates immune responses by inhibiting the ability of APCs to present antigens to T cells in a variety of ways. The mechanisms of IL-10-mediated immunosuppression include interference in TLR-mediated or IFNγ-mediated dendritic cell (DC) and macrophage activation as well as direct induction of genes that suppress APC function. In this review we will discuss current studies exploring the molecular mechanisms by which IL-10 suppresses APC function.

PMID:
25597442
PMCID:
PMC4444374
DOI:
10.1016/j.coi.2014.12.009
[Indexed for MEDLINE]
Free PMC Article

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