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J Med Chem. 2015 Feb 12;58(3):1298-306. doi: 10.1021/jm5015082. Epub 2015 Feb 3.

Development of potent inhibitors of pyocyanin production in Pseudomonas aeruginosa.

Author information

1
Department of Chemistry and ‡Department of Molecular Biology, Princeton University , Washington Road, Princeton, New Jersey 08544, United States.

Abstract

The development of new approaches for the treatment of antimicrobial-resistant infections is an urgent public health priority. The Pseudomonas aeruginosa pathogen, in particular, is a leading source of infection in hospital settings, with few available treatment options. In the context of an effort to develop antivirulence strategies to combat bacterial infection, we identified a series of highly effective small molecules that inhibit the production of pyocyanin, a redox-active virulence factor produced by P. aeruginosa. Interestingly, these new antagonists appear to suppress P. aeruginosa virulence factor production through a pathway that is independent of LasR and RhlR.

PMID:
25597392
PMCID:
PMC4332565
DOI:
10.1021/jm5015082
[Indexed for MEDLINE]
Free PMC Article

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