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Adv Healthc Mater. 2015 Apr 22;4(6):831-7. doi: 10.1002/adhm.201400809. Epub 2015 Jan 19.

Collagen Scaffolds Incorporating Coincident Gradations of Instructive Structural and Biochemical Cues for Osteotendinous Junction Engineering.

Author information

1
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 104 RAL, 600 S. Mathews Ave., Urbana, IL, 61801, USA.

Abstract

A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.

KEYWORDS:

bone; collagen; mesenchymal stem cells; orthopedic interfaces; tendon

PMID:
25597299
PMCID:
PMC4409544
DOI:
10.1002/adhm.201400809
[Indexed for MEDLINE]
Free PMC Article

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