Format

Send to

Choose Destination
Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2822-33. doi: 10.1016/j.bbamcr.2014.12.040. Epub 2015 Jan 13.

Mitochondrial dynamics and viral infections: A close nexus.

Author information

1
Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
2
Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address: asiddiqui@ucsd.edu.

Abstract

Viruses manipulate cellular machinery and functions to subvert intracellular environment conducive for viral proliferation. They strategically alter functions of the multitasking mitochondria to influence energy production, metabolism, survival, and immune signaling. Mitochondria either occur as heterogeneous population of individual organelles or large interconnected tubular network. The mitochondrial network is highly susceptible to physiological and environmental insults, including viral infections, and is dynamically maintained by mitochondrial fission and fusion. Mitochondrial dynamics in tandem with mitochondria-selective autophagy 'mitophagy' coordinates mitochondrial quality control and homeostasis. Mitochondrial dynamics impacts cellular homeostasis, metabolism, and innate-immune signaling, and thus can be major determinant of the outcome of viral infections. Herein, we review how mitochondrial dynamics is affected during viral infections and how this complex interplay benefits the viral infectious process and associated diseases.

KEYWORDS:

Hepatitis virus; Innate immunity; Mitochondrial fission and fusion; Mitophagy; Virus

PMID:
25595529
PMCID:
PMC4500740
DOI:
10.1016/j.bbamcr.2014.12.040
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center