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Neuroimage. 2015 Apr 1;109:190-8. doi: 10.1016/j.neuroimage.2015.01.027. Epub 2015 Jan 14.

Environmental enrichment is associated with rapid volumetric brain changes in adult mice.

Author information

1
Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: jan.scholz@mouseimaging.ca.
2
Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
3
Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada.

Abstract

Environmental enrichment is a model of increased structural brain plasticity. Previous histological observations have shown molecular and cellular changes in a few pre-determined areas of the rodent brain. However, little is known about the time course of enrichment-induced brain changes and how they distribute across the whole brain. Here we expose adult mice to three weeks of environmental enrichment using a novel re-configurable maze design. In-vivo MRI shows volumetric brain changes in brain areas related to spatial memory, navigation, and sensorimotor experience, such as the hippocampal formation and the sensorimotor cortex. Evidence from a second cohort of mice indicates that these plastic changes might occur as early as 24h after exposure. This suggests that novel experiences are powerful modulators of plasticity even in the adult brain. Understanding and harnessing the underlying molecular mechanisms could advance future treatments of neurological disease.

KEYWORDS:

DBM; Environmental enrichment; In-vivo MRI; Maze; Mice

[Indexed for MEDLINE]

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