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Gene. 2015 Mar 15;559(1):73-6. doi: 10.1016/j.gene.2015.01.022. Epub 2015 Jan 14.

Association between vitamin D concentration and levels of sex hormones in an elderly Polish population with different genotypes of VDR polymorphisms (rs10735810, rs1544410, rs7975232, rs731236).

Author information

1
Department of Endocrinology and Diabetology, Wroclaw Medical University, Wroclaw, Poland. Electronic address: Lukasz.laczmanski@umed.wroc.pl.
2
Department of Health Promotion, Faculty of Physiotherapy, University School of Physical Education, Wroclaw, Poland.
3
PolSenior Project, International Institute of Molecular and Cell Biology, Warsaw, Poland.
4
Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland; Department of Geriatrics and Gerontology, Medical Centre of Postgraduate Education, Warsaw, Poland.
5
Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
6
Department of Endocrinology and Diabetology, Wroclaw Medical University, Wroclaw, Poland.
7
Department of Hypertension and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
8
Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
9
Department of Pathophysiology, Medical University of Silesia, Katowice, Poland.

Abstract

BACKGROUND:

Vitamin D co-regulates the synthesis of sex hormones in part by interaction with its nuclear receptor. The aim of this study was to determine whether there is an association of vitamin D concentration vs the level of sex hormones in elderly Polish individuals with different genotypes of the vitamin D receptor (VDR) gene.

MATERIALS AND METHODS:

Rs10735810, rs1544410, rs7975232, and rs731236 polymorphisms of VDR, the serum sex hormone level, free estrogen index (FEI) and free androgen index (FAI) as well as vitamin D, were evaluated in 766 persons (362 women and 404 men) selected from 5695 Polish population, aged 65-90years from the PolSenior survey.

RESULTS:

We observed that women with GG (rs731236), TT (rs7975232), BB (rs1544410) and FF (rs10735810) genotypes were characterized by a significant correlation between vitamin D vs testosterone concentration and FAI value. We found a significant correlation between testosterone level and FAI vs vitamin D concentration in men with heterozygote AG in the rs731236 polymorphism and in the GG (rs7975232), the BB (rs1544410), and the Ff (rs10735810) genotypes.

CONCLUSION:

In elderly selected Polish population with different genotypes of VDR polymorphisms, a statistically significant relationship between vitamin D concentration vs testosterone level was observed.

KEYWORDS:

Aging; FAI; Testosterone level; VDR polymorphism; Vitamin D level

PMID:
25595352
DOI:
10.1016/j.gene.2015.01.022
[Indexed for MEDLINE]

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