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Am J Otolaryngol. 2015 May-Jun;36(3):352-5. doi: 10.1016/j.amjoto.2014.12.008. Epub 2014 Dec 24.

Recurrent squamous cell carcinoma of the temporal bone: critical analysis of cases with a poor prognosis.

Author information

1
Department of Neurosciences, Otolaryngology Section, Padova University, Padova, Italy.
2
Department of Neurosciences, Otolaryngology Section, Padova University, Padova, Italy. Electronic address: gino.marioni@unipd.it.
3
Department of Medicine DIMED, Padova University, Padova, Italy.
4
Department of Neurosciences, Otolaryngology Section, Padova University, Padova, Italy; (formerly) ENT Unit, Ospedali Riuniti Bergamo, Bergamo, Italy.

Abstract

PURPOSE:

Temporal bone squamous cell carcinoma (TBSCC) is an uncommon, aggressive malignancy with a significant recurrence rate. We reviewed our experience with recurrent TBSCCs.

MATERIALS AND METHODS:

Clinicopathological and therapeutic variables potentially associated with disease-free survival (DFS) and disease-specific survival (DSS) were assessed in 17 TBSCC patients who died of their disease after treatment.

RESULTS:

TBSCC recurrences were treated with surgery in 12 cases (palliative in 11, with curative intent in 1) and palliative chemotherapy in 5; the median DFS and DSS were 6 and 16 months, respectively. The mean DFS and DSS were longer in patients who had primary lateral temporal bone resection (LTBR) rather than subtotal temporal bone resection (STBR) (p=0.0173 and p=0.03, respectively). Patients given non-surgical palliative treatment for recurrences had a longer mean DSS than those who underwent surgery (trend toward significance, p=0.09).

CONCLUSIONS:

Our results reflect the aggressive nature of TBSCC recurrences. Our findings seem to support the use of non-surgical treatments (chemotherapy, radiotherapy, or specialist palliative care) in patients with loco-regionally advanced recurrent TBSCC. Salvage surgery might be considered for early recurrences when radicality is still achievable. Precise guidelines for the rational follow-up of surgically-treated TBSCCs need to be shared between tertiary centers.

PMID:
25595048
DOI:
10.1016/j.amjoto.2014.12.008
[Indexed for MEDLINE]

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