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Neurosci Lett. 1989 Dec 15;107(1-3):26-32.

Stimulation of the rostral ventrolateral medullary neurons increases cortical cerebral blood flow via activation of the intracerebral neural pathway.

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Department of Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.


In urethane-anesthetized, artificially ventilated rats, electrical or chemical (by L-glutamate) focal stimulations of the rostral ventrolateral medulla (RVLM) produced an increase in cortical cerebral blood flow (CBF). The RVLM-induced cortical vasodilative response was present in animals with spinal cords sectioned at levels of Th3-4 and with bilateral extracerebral cervical sympathetic trunks (CSTs) severed. The RVLM-induced cortical vasodilative response was totally eliminated by an alpha 2 adrenergic blocker, but not by blockers for muscarinic, nicotinic, alpha 1 and beta receptors. It was concluded that there is an intracerebral vasodilative neural pathway including an alpha 2 adrenergic receptor originating in the RVLM for regulation of cortical blood vessels.

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