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Nanoscale Res Lett. 2014 Dec 4;9(1):656. doi: 10.1186/1556-276X-9-656. eCollection 2014.

Chemical and magnetic functionalization of graphene oxide as a route to enhance its biocompatibility.

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Institute of Chemical and Environment Engineering, West Pomeranian University of Technology, Szczecin, Piastow Avenue 45, Szczecin 70-311, Poland.
Laboratory of Cytogenetics, West Pomeranian University of Technology, Szczecin, Judyma 6, Szczecin 71-466, Poland.
Institute of Chemical Engineering and Environmental Protection Process, West Pomeranian University of Technology, Szczecin, Piastow Avenue 42, Szczecin 71-065, Poland.


The novel approach for deposition of iron oxide nanoparticles with narrow size distribution supported on different sized graphene oxide was reported. Two different samples with different size distributions of graphene oxide (0.5 to 7 μm and 1 to 3 μm) were selectively prepared, and the influence of the flake size distribution on the mitochondrial activity of L929 with WST1 assay in vitro study was also evaluated. Little reduction of mitochondrial activity of the GO-Fe3O4 samples with broader size distribution (0.5 to 7 μm) was observed. The pristine GO samples (0.5 to 7 μm) in the highest concentrations reduced the mitochondrial activity significantly. For GO-Fe3O4 samples with narrower size distribution, the best biocompatibility was noticed at concentration 12.5 μg/mL. The highest reduction of cell viability was noted at a dose 100 μg/mL for GO (1 to 3 μm). It is worth noting that the chemical functionalization of GO and Fe3O4 is a way to enhance the biocompatibility and makes the system independent of the size distribution of graphene oxide.


Biocompatibility; Graphene oxide; Magnetic nanoparticles

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