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Trends Cell Biol. 2015 May;25(5):249-64. doi: 10.1016/j.tcb.2014.12.004. Epub 2015 Jan 12.

BMP signalling: agony and antagony in the family.

Author information

1
Centre for Experimental Medicine, Queen's University Belfast, Belfast BT12 6BA, UK. Electronic address: d.brazil@qub.ac.uk.
2
Centre for Experimental Medicine, Queen's University Belfast, Belfast BT12 6BA, UK.
3
UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
4
UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: finian.martin@ucd.ie.

Abstract

Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.

KEYWORDS:

Gremlin; antagonist; bone morphogenetic proteins; disease; miRNA

PMID:
25592806
DOI:
10.1016/j.tcb.2014.12.004
[Indexed for MEDLINE]

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