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JACC Cardiovasc Imaging. 2015 Jan;8(1):76-82. doi: 10.1016/j.jcmg.2014.08.012. Epub 2014 Nov 1.

Association of myocardial T1-mapping CMR with hemodynamics and RV performance in pulmonary hypertension.

Author information

1
Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. Electronic address: ana.garcia@cnic.es.
2
Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Universitario Quirón Madrid, Universidad Europea de Madrid, Madrid, Spain.
3
Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
4
Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Clínico San Carlos, Madrid, Spain.
5
Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Philips Healthcare Iberia, Madrid, Spain.
6
Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Puerta de Hierro, Madrid, Spain.
7
Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain.
8
Facultad de Medicina, Universidad de Extremadura, Badajoz, Spain.
9
Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Universitario Montepríncipe, Madrid, Spain.
10
Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Universitario Central de Asturias, Oviedo, Spain.
11
Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
12
Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
13
Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
14
Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain; Hospital Clínico San Carlos, Madrid, Spain. Electronic address: bibanez@cnic.es.

Abstract

Early detection of right ventricular (RV) involvement in chronic pulmonary hypertension (PH) is essential due to prognostic implications. T1 mapping by cardiac magnetic resonance (CMR) has emerged as a noninvasive technique for extracellular volume fraction (ECV) quantification. We assessed the association of myocardial native T1 time and equilibrium contrast ECV (Eq-ECV) at the RV insertion points with pulmonary hemodynamics and RV performance in an experimental model of chronic PH. Right heart catheterization followed by immediate CMR was performed on 38 pigs with chronic PH (generated by surgical pulmonary vein banding) and 6 sham-operated controls. Native T1 and Eq-ECV values at the RV insertion points were both significantly higher in banded animals than in controls and showed significant correlation with pulmonary hemodynamics, RV arterial coupling, and RV performance. Eq-ECV values also increased before overt RV systolic dysfunction, offering potential for the early detection of myocardial involvement in chronic PH.

KEYWORDS:

T1 mapping; equilibrium contrast; extracellular volume; magnetic resonance; native T1; pulmonary hypertension

PMID:
25592698
DOI:
10.1016/j.jcmg.2014.08.012
[Indexed for MEDLINE]
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