Format

Send to

Choose Destination
Nat Rev Cancer. 2015 Feb;15(2):73-79. doi: 10.1038/nrc3876. Epub 2015 Jan 16.

The emerging roles of YAP and TAZ in cancer.

Author information

1
Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.
#
Contributed equally

Abstract

Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. We also highlight recent findings on their expanding role in cancer progression and describe the potential of these targets for therapeutic intervention.

PMID:
25592648
PMCID:
PMC4562315
DOI:
10.1038/nrc3876
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center