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Nature. 2015 Jan 15;517(7534):293-301. doi: 10.1038/nature14189.

The biology of innate lymphoid cells.

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Weill Cornell Medical College, Cornell University, New York, New York 10021, USA.
Academic Medical Center at the University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.


The innate immune system is composed of a diverse array of evolutionarily ancient haematopoietic cell types, including dendritic cells, monocytes, macrophages and granulocytes. These cell populations collaborate with each other, with the adaptive immune system and with non-haematopoietic cells to promote immunity, inflammation and tissue repair. Innate lymphoid cells are the most recently identified constituents of the innate immune system and have been the focus of intense investigation over the past five years. We summarize the studies that formally identified innate lymphoid cells and highlight their emerging roles in controlling tissue homeostasis in the context of infection, chronic inflammation, metabolic disease and cancer.

[Indexed for MEDLINE]

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